Labrador+Centronuclear+Myopathy

Centronuclear Myopathy, also known as HMLR, or hereditary myopathy, is a recessive mutation that causes weak muscle function in the Labrador Retriever breed. This is caused by nuclei in muscle fibers. Labrador Retriever puppies are born normal but it soon becomes evident that there is an abnormality. The puppy will not gain weight, due to decreased muscle tone in the esophagus. By the time it has been 2 to 5 months, the disease has usually increased and it is obvious to the symptoms, extreme intolerance to exercise and awkward gait are just some of them. Sadly, there is no cure for Centronuclear Myopathy causing the dog to never develop normal muscle tissue.
 * centronuclear myopathy

Since Centronuclear Myopathy is a recessive disorder, the only way a dog can have this disease is if it has two copies of the gene. A problem with it being recessive is that the dog can carry one copy of the mutation and not show any signs of a problem. A carrier dog can give this disease to their offspring. DNA testing is available to people with dogs who carry the disease.**